Hydrogen Sulfide Donors Cardiovascular SYstem - 1487 Words

Hydrogen sulfide donors in the cardiovascular system Since the evolution of H2S as an essential gasotransmitter at cellular level, and based on the fact that H2S characteristically similar to NO; researchers aimed to investigate the physiological effects of H2S on cardiovascular system, proposing that H2S donors may become a potential treatment for various cardiovascular abnormalities including atherosclerosis, hypertension, vasoconstriction and cellular apoptosis induced by reactive oxygen species [24-26]. The cellular mechanism by which H2S induce cardiovascular effects is not well illustrated yet. A recent study suggested that H2S can reduce heart rate and blood pressure through KATP channel activation when intracerebroventricular NaHS (H2S donor) significantly reduced the blood pressure and heart rate of experimental rats, while Glibenclamide, a potent KATP channel blocker, effectively attenuated and reversed the effect of NaHS on heart rate and blood pressure [38]. Effect on nitric oxide release A recent study investigated the effect of H2S deficiency on endothelial NO synthase (eNOS) function, NO production, and ischemia / reperfusion injury by on CSE- knocked out mice and control [12]. Significant Lower H2S levels among CSE- knocked out mice was confirmed by gas chromatography. From oxidative stress perspective; their results revealed significant higher levels of malondialdehyde (indicator for lipid peroxidation) in heart muscle among CSE- knocked out mice compared toShow MoreRelatedHydrogen Sulfide: New Gaseous Signaling Molecule in the Cardiovascular System 1010 Words   |  4 PagesIntroduction: Hydrogen sulfide (H2S) is the latest molecule added to the gasotransmitter group after nitric oxide (NO) and carbon monoxide (CO). Great attention has been given to H2S in the last few years with regards to its production, metabolism, physiological functions and clearance. H2S constitutes a sound example of science’s evolution based on research and development; since H2S has been named as a toxic gas since its discovery in 1713, and only in the late 80’s of the past century scientist